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The Big Brain was the evil overlord brain from the futuristic world that Timmy Turner wished for in "Future Lost". It serves as the main antagonist of the episode.
Description[]
The giant floating brain was housed in a facility in Antarctica and lived in a glass jar that fed it "brain nutrients" and that had an antenna on the top. Out of boredom, Big Brain decided to use his mind-control robots so that they would consider themselves to be the superior species and enslave all humans to serve their will.
Background[]

The end of the Big Brain
The Big Brain was created as a result of Timmy Turner's wish for everything in the world to be like what it was in a Stevie Sparks science fiction book, which Timmy did not know was a story about robots turning evil and subjugating humanity. With the help of Mark Chang and Mr. Crocker, Timmy defeated the Big Brain by turning its jar into a big slushie, which gave the brain "brain freeze" and made it literally freeze. If it was not destroyed by that event, it was most certainly unwished when Timmy wished the world back to normal.